Erectile Dysfunction and Other Urological Disorders

Stiffening of blood vessels and endothelial dysfunction in diabetes typically results in erectile dysfunction in diabetic or hypertensive patients. Evaluation of inhibitors of advanced glycation endproducts and more recently crosslink breakers in preclinical studies with diabetic rats has indicated the potential for clinical utility of these compounds.

Erectile Dysfunction

The Breakdown of Preformed Advanced Glycation End Products Reverses Erectile Dysfunction in Streptozotocin-Induced Diabetic Rats: Preventive Versus Curative Treatment
Author: Usta MF, et al.
Source: J Sex Med 2006;3:242–252

Role of Oxidative Stress in Pathophysiology of Erectile Dysfunction
Author: Agarwal, et al.
Source: Published-Ahead-of-Print on December 8, 2005 by Journal of Andrology

Erectile Dysfunction in the Patient With Diabetes Mellitus
Author: Martyn A. Vickers, MD and Eric A. Wright, PharmD, BCPS
Source: The American Journal of Managed Care, Vol. 10, No. 1., January 2004

Impaired Brachial Artery Endothelium-Dependent and -Independent Vasodilation in Men With Erectile Dysfunction and No Other Clinical Cardiovascular Disease
Author: Kaiser, et al
Source: Journal of the American College of Cardiology, Vol. 43, No. 2, 2004

Treatment Options for Erectile Dysfunction in Patients Failing Oral Drug Therapy
Author: Konstantinos Hatzimouratidis and Dimitrios G. Hatzichristou
Source: European Association of Urology, Series 2, 75-83, 2004

Relationship Between Erectile Dysfunction and Silent Myocardial Ischemia in Apparently Uncomplicated Type 2 Diabetic Patients
Author: Gazzaruso, Carmine MD, et al
Source: Circulation, 110, 2004

Erectile Dysfunction: An Early Marker for Hypertension? A Longitudinal Study in Spontaneously Hypertensive Rats
Author: Behr-Lroussel, Delphine, et al
Source: American Journal Physiology, Regulatory, Integrative and Comparative Physiology, 2004

Diabetes and Erectile Dysfunction
Author: John Gore, MD and Jacob Rajfer, MD
Source: Current Science Inc., 1:87-91, 2004

Impaired Brachial Artery Endothelium-Dependent and –Independent Vasodilation in Men With Erectile Dysfunction and No Other Clinical Cardiovascular Disease
Author: Kaiser, Daniel R., PhD, et al
Source: Journal of the American College of Cardiology, Vo. 43, No. 2, 2004

The Protective Effect of Aminoguanidine on Erectile Function in Streptozotocin Diabetic Rats
Author: Usta M., et al.
Source: The Journal of Urology, Vol. 170, 1437-1442, October 2003

Endothelial Dysfunction in Erectile Dysfunction: Role of the Endothelium in Erectile Physiology and Disease
Author: Bivalacqua, Trinity J., et al.
Source: Journal of Andrology, Vol. 24, No. 6 Supplement, November/December 2003

Vardenafil for Treatment of Men With Erectile Dysfunction: Efficacy and Safety in a Randomized, Double-Blind, Placebo-Controlled Trial
Author: Hellstrom W., et al
Source: Journal of Andrology, Vol. 23, No. 6, November/December 2002

Impact of Chronic Renal Failure and Peritoneal Dialysis Fluids on Advanced End Product and iNOS Levels in Penile Tissue: An Experimental Study
Author: Usta M., et al.
Source: Urology 59: 953-957, 2002

Advanced Glycation End-Products are Responsible for the Impairment of Corpus Cavernosal Smooth Muscle Relaxation Seen in Diabetes
Author: Cartledge, JJ., et al.
Source: British Journal of Urological Surgeons, 2001

Nitric Oxide-Mediated Corpus Cavernosal Smooth Muscle Relaxation is Impaired in Ageing and Diabetes
Author: Cartledge, JJ., et al
Source: British Journal of Urological Surgeons, 2001

Erectile Dysfunction
Author: Tom F. Lue, M.D., Alastair J.J. Wood, M.D., Editor
Source: The New England Journal of Medicine, June 2000

Advanced Glycation End Products in Human Penis: Elevation in Diabetic Tissue, Site of Deposition, and Possible Effect Through iNOS or eNOS
Author: Seftel A., et al
Source: Urology 50: 1016-1026, 1997

Urological Disorders

The Protective Effect of Aminoguanidine on Erectile Function in Streptozotocin Diabetic Rats
Author: Usta, et al.
Source: The Journal of Urology, Vol. 170, 1437–1442, October 2003

The Potential Role of Advanced Glycation End Product and iNOS in Chronic Renal Failure-Related Testicular Dysfunction. An Experimental Study
Author: Koksal, et al.
Source: American Journal of Nephrology, 2003, 23(5):361-8

The Involvement of Advanced Glycation Endproducts (AGEs) in Renal Injury of Diabetic Glomerulosclerosis: Association With Phenotypic Change in Renal Cells and Infiltration of Immune Cells
Author: Mao, et al.
Source: Clinical and Experimental Nephrology, 2003, 7(3):201-9

Advanced Glycation in Uraemic Toxicity
Author: van Ypersele de Strihou
Source: EDTNA/ERCA Journal, July-September 2003, 29(3):148-50

Pathophysiology of Diabetic Sexual Dysfunction
Author: Morano
Source: Journal of Endocrinocological Investigation, 2003, 26(3 Suppl):65-9