Role of A.G.E.s in Human Pathology

The non-enzymatic crosslinking of tissues and extracellular matrix, which occurs in normal aging and is enhanced in diabetes, leads to multi-organ system pathology. Generation of reactive oxygen species and oxidative stress contributes to inflammation and metabolic imbalance. Complications of diabetes such as retinopathy, nephropathy, hypertension and elevated risk of atherosclerosis are thought to result from the enhanced matrix deposition that is driven by the underlying inflammatory component in these syndromes.

Inhibitory Effects of Amlodipine and Fluvastatin on the Deposition of Advanced Glycation End Products in Aortic Wall of Cholesterol and Fructose-Fed Rabbits
Author: Akira, et al
Source: Biol. Pharm. Bull. 29(1) 75—81 (2006)

Advanced Glycation End Products and the Kidney
Author: Bohlender, et al
Source: AJP - Renal 289:645-659, 2005

Advanced Glycosylation End Products Might Promote Atherosclerosis Through Inducing the Immune Maturation of Dendritic Cells
Author: Ge, et al
Source: Arterioscler Thromb Vasc Biol. 2005;25:2157-2163.

Interactions between Renin Angiotensin System and Advanced Glycation in the Kidney
Author: Thomas, et al
Source: J Am Soc Nephrol 16: 2976–2984, 2005

Banting Lecture 2004: The Pathobiology of Diabetic Complications - A Unifying Mechanism
Author: Michael Brownlee
Source: Diabetes, VOL. 54, June 2005

Impaired Retinal Angiogenesis in Diabetes: Role of Advanced Glycation End Products and Galectin-3
Author: Stitt, et al
Source: Diabetes, VOL. 53, March 2005

Advanced Glycation End-Product Cross-Link Breakers
Author: Bakris, et al
Source: American Journal of Hypertension, 17:23S–30S, August 2004

Advanced Glycation End-Products and the Progress of Diabetic Vascular Complications
Author: Jakus and Rietbrock
Source: Physiology Research, 2004, 53: 131-142

Protein Glycation: A Firm Link to Endothelial Cell Dysfunction
Author: Wautier and Schmidt, Editor - David A. Kass
Source: Circulation Research, 2004, 95:233-238

Glycoxidation: The Menace of Diabetes and Aging
Author: Vlassara, et al.
Source: The Mount Sinai Journal of Medicine, Vol. 70, No. 4, September 2003

Impact of Metabolic Control and Serum Lipids on the Concentration of Advanced Glycation End Products in the Serum of Children and Adolescents With Type 1 Diabetes, as Determined by Fluorescence Spectroscopy and Ne-(Carboxymethyl) Lysine ELISA
Author: Galler, et al.
Source: Diabetes Care, Vol. 26, No. 9, September 2003

Diabetes-Induced Oxidative Stress and Low-Grade Inflammation in Porcine Coronary Arteries
Author: Zhang L, et al
Source: Circulation, July 2003

Glycated Collagen Cross-linking Alters Cardiac Mechanics in Volume-overload Hypertrophy
Author: Herrmann K, et al
Source: American Journal Physiology Heart Circulatory Physiology, April 2003

Glucose, Advanced Glycation End Products, and Diabetes Complications: What Is New and What Works
Author: Peppa, et al.
Source: Clinical Diabetes, Vol. 21, No. 4, 2003

Glycation—A Sweet Tempter for Neuronal Death
Author: Kikuchi, et al.
Source: Brain Research Reviews, 2003, 41, 306–323

Glycation, Inflammation, and RAGE - A Scaffold for the Macrovascular Complications of Diabetes and Beyond
Author: Yan, et al.
Source: Circulation Research, 2003, 93:1159-1169

Glycation and Diabetes: The RAGE Connection
Author: Hudson B, et al
Source: December 2002

Sugar and Cardiovascular Disease
Author: Howard B and Wylie-Rosett J
Source: July 2002

Advanced Glycation End Products and Endothelial Dysfunction in Type 2 Diabetes
Author: Tan, et al.
Source: Diabetes Care, Vol. 25, No. 6, June 2002

Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE
Author: Basta, et al.
Source: Circulation, 2002, 105:816-822

Advanced Glycation End-Products and Advanced Oxidation Protein Products in Patients with Diabetes Mellitus
Author: Kalousova, et al.
Source: Physiology Research, 2002, 51: 597-604

Advanced Glycosylation End Products Up-Regulate Connective Tissue Growth Factor (Insulin-Like Growth Factor-Binding Protein-Related Protein 2) in Human Fibroblasts: A Potential Mechanism for Expansion of Extracellular Matrix in Diabetes Mellitus
Author: Twigg, et al.
Source: Endocrinology, 2001, 142: 1760–1769

Protein Glycation, Diabetes, and Aging
Author: Ulrich and Cerami
Source: The Endocrine Society, 2001

Negative Consequences of Glycation
Author: Brownlee M
Source: Metabolism, February 2000

Making Sense of Advanced Glycation Endproducts (AGE)
Author: Hanssen
Source: International Diabetes Monitor, Vol. 10, No. 4, 1998