Respiratory

Stiffening of respiratory tissues may contribute to emphysema. A non-compliant vasculature in the lung contributes to a compromise in cardiac function leading to heart failure. A.G.E.s accumulate in pulmonary collagen with diabetes and increasing age.

Expression of S100A12 (EN-RAGE) in Cystic Fibrosis
Author: Foell, et al.
Source: Thorax, July 2003, 58(7):613-7

Structural and Transport Property Alterations of the Lung Capillary Endothelium in Diabetes
Author: Popov and Simionescu
Source: Italian Journal of Anatomy and Embryology, 2001, 106(2 Suppl 1):405-12

Receptor for Advanced Glycation Endproducts (RAGE) Exhibits Highly Differential Cellular and Subcellular Localisation in Rat and Human Lung
Author: Fehrenbach, et al.
Source: Cellular and Molecular Biology (Noisy-le-grand), November 1998, 44(7):1147-57

Immunohistochemical Localisation of Advanced Glycation End Products in Pulmonary Fibrosis
Author: Matsuse, et al.
Source: Journal of Clinical Pathology. Ju1y 1998, 51(7):515-9

Type II Alveolar Epithelial Cells in Lung Express Receptor for Advanced Glycation End Products (RAGE) Gene
Author: Katsuoka, et al.
Source: Biochemical and Biophysical Research Communications, 1997, 238(2):512-6

Age-Related Fluorescence in Rat Lung Collagen
Author: Bellmunt, et al.
Source: Lung, 1995, 173(3):177-85