Receptor for A.G.E.s (RAGE)

There are many cellular receptors for A.G.E.s including RAGE. Binding and activation of the RAGE receptor is thought to be responsible for many of the pathologic insults such as inflammation and matrix deposition. Blockade of the receptor by soluble RAGE or by antibodies has confirmed the important role of this receptor in disease pathophysiology.

Receptor for Advanced Glycation End Products and Its Ligands
Author: Kim, et al.
Source: Ann. N.Y. Acad. Sci. 1043: 553–561, 2005

Receptor for Advanced Glycation End Products Is a Promising Target of Diabetic Nephropathy
Author: Yamamoto, et al.
Source: Ann. N.Y. Acad. Sci. 1043: 562–566, 2005

Glycation, Inflammation, and RAGE - A Scaffold for the Macrovascular Complications of Diabetes and Beyond
Author: Yan, et al.
Source: Circulation Research, 2003, 93:1159-1169

Receptor for AGE (RAGE) Mediates Neointimal Formation in Response to Arterial Injury
Author: Zhou, et al.
Source: Circulation, 2003, 107:2238-2243

The Receptor RAGE as a Progression Factor Amplifying Arachidonate-Dependent Inflammatory and Proteolytic Response in Human Atherosclerotic Plaques
Author: Cipollone, et al.
Source: Circulation, 2003, 108:1070-1077

Glycation and Diabetes: The RAGE Connection
Author: Hudson, et al.
Source: Current Science, Vol. 83, No. 12, 25 December 2002

Advanced Glycation End Products Activate Endothelium Through Signal-Transduction Receptor RAGE
Author: Basta, et al.
Source: Circulation, 2002, 105:816-822

Blockade of Receptor for Advanced Glycation End-Products Restores Effective Wound Healing in Diabetic Mice
Author: Goova, et al.
Source: American Journal of Pathology, Vol. 159, No. 2, August 2001

The Multiligand Receptor RAGE as a Progression Factor Amplifying Immune and Inflammatory Responses
Author: Schmidt, et al.
Source: The Journal of Clinical Investigation, 2001, 108:949–955