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Other Disorders
The binding of A.G.E.s to a relevant cellular receptor (RAGE) is associated with an amplification of the inflammatory response. Resolution of this inflammation by matrix deposition leads to tissue impairment or organ failure. A.G.E.s are also implicated in wound healing and arterial restenosis after stent placement. Endothelial dysfunction - one of the hallmarks of obesity, hypertension and diabetes - may be a root cause of atherosclerosis. This impaired vasodilation response leads to pathologic responses in the heart resulting in heart failure. A role for A.G.E. involvement in tumor metastasis has also been postulated. Synvista is evaluating the role of alagebrium in clinical trials on endothelial dysfunction.
Inflammation and Atherosclerosis
Author: Shishehbor and Bhatt
Source: Current Atherosclerosis Reports, 2004, 6:131–139
Blockade of Advanced Glycation End-Product Formation Restores Ischemia-Induced Angiogenesis in Diabetic Mice
Author: Tamarat, et al.
Source: Proceedings of the National Academy of Sciences, Vol. 100, No. 14, 8555–8560, July 8, 2003
Preferential Stiffening of Central Over Peripheral Arteries in Type 2 Diabetes
Author: Kimoto, et al.
Source: Diabetes, Vol. 52, February 2003
Advanced Glycation End-Product (AGE)-Damaged IgG and IgM Autoantibodies to IgG-AGE in Patients with Early Synovitis
Author: Newkirk, et al.
Source: Arthritis Research and Therapy, Vol. 5, No. 2, 2003
Diabetes-Induced Oxidative Stress and Low-Grade Inflammation in Porcine Coronary Arteries
Author: Zhang, et al.
Source: Circulation, 2003, 108: 472-478
Glycation, Inflammation, and RAGE - A Scaffold for the Macrovascular Complications of Diabetes and Beyond
Author: Yan, et al.
Source: Circulation Research, 2003, 93:1159-1169
Pentosidine and Ne-(carboxymethyl)-Lysine in Alzheimer’s Disease and Vascular Dementia
Author: Bär, et al.
Source: Neurobiology of Aging, 2003, 24:333–338
Receptor for AGE (RAGE) Mediates Neointimal Formation in Response to Arterial Injury
Author: Zhou, et al.
Source: Circulation, 2003, 107:2238-2243
Carbonyl Toxicology and Alzheimer’s Disease
Author: Picklo, et al.
Source: Toxicology and Applied Pharmacology, 2002, 184, 187–197
Vascular Smooth Muscle Cell Activation by Glycated Albumin (Amadori Adducts)
Author: Hattori, et al.
Source: Hypertension, 2002, 39:22-28
Inflammation in Nonhealing Diabetic Wounds
Author: Pierce
Source: American Journal of Pathology, Vol. 159, No. 2, August 2001
NF-kB: Pivotal Mediator or Innocent Bystander in Atherogenesis?
Author: Collins and Cybulsky
Source: The Journal of Clinical Investigation, Vol. 107, No. 3, February 2001
AGES in Brain Ageing: AGE-Inhibitors as Neuroprotective and Anti-Dementia Drugs?
Author: Dukic-Stefanovic, et al.
Source: Biogerontology, 2001, 2: 19–34
The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
Author: Schmidt, et al.
Source: The Journal of Clinical Investigation, 2001, 108:949–955
Longitudinal Determination of Skin Collagen Glycation and Glycoxidation Rates Predicts Early Death in C57BL/6NNIA Mice
Author: Sell, et al.
Source: The Federation of American Societies for Experimental Biology (FASEB) Journal, Vol. 14, January 2000
Skin Collagen Glycation, Glycoxidation, and Crosslinking Are Lower in Subjects With Long-Term Intensive Versus Conventional Therapy of Type 1 Diabetes
Author: Monnier, et al.
Source: Diabetes, Vol. 48, April 1999
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