Ophthalmic

A.G.E.s accumulate in the central nervous system in neurofibrillary tangles and plaque which are associated with Alzheimer’s disease. Additionally, it is thought that the reactive oxygen species associated with the presence of A.G.E.s is in part responsible for neuronal death in Alzheimer’s disease. Synvista is supporting preclinical research in this area of interest.

Impaired Retinal Angiogenesis in Diabetes: Role of Advanced Glycation End Products and Galectin-3
Author: Stitt, et al
Source: Diabetes, VOL. 53, March 2005

The Maillard Reaction in Eye Diseases
Author: Alan W. Stitt
Source: Ann. N.Y. Acad. Sci. 1043: 582–597, 2005

Substrates modified by advanced glycation end-products cause dysfunction and death in retinal pericytes by reducing survival signals mediated by platelet-derived growth factor
Author: Stitt, et al.
Source: Diabetologia. 2004 Oct 22

The Role of Advanced Glycation in the Pathogenesis of Diabetic Retinopathy
Author: Stitt
Source: Experimental and Molecular Pathology, August, 2003, 75(1): 95-108

Advanced Glycation Endproducts in Human Diabetic and Non-Diabetic Cataractous Lenses
Author: Pokupec, et al.
Source: Graefe's Archive for Clinical and Experimental Ophthalmology, May 2003, 241(5): 378-84

Cleavage of in Vitro and in Vivo Formed Lens Protein Cross-Links by a Novel Cross-Link Breaker
Author: Hollenbach, et al.
Source: Molecular Cell Biochemistry, January 2003, 243(1-2):73-80

OP-Lysine is a Newly Identified Advanced Glycation Endproduct in Cataractous and Aged Human Lenses
Author: Argirov, et al.
Source: The American Society for Biochemistry and Molecular Biology, Inc., 2003

Alteration of the Intracellular pH and Apoptosis Induction in a Retinal Cell Line by the AGE-Inducing Agent Glyoxal
Author: Kasper, et al.
Source: Graefe's Archive for Clinical and Experimental Ophthalmology , December 2002, 240(12):1022-32

Immunolocalization and Quantification of Advanced Glycation End Products in Retinal Neovascular Membranes and Serum: A Possible Role in Ocular Neovascularization
Author: Swamy-Mruthinti, et al.
Source: Current Eye Research, September 2002, 25(3):139-45

Pigment Epithelium-Derived Factor Protects Cultured Retinal Pericytes From Advanced Glycation End Product-Induced Injury Through its Antioxidative Properties
Author: Yamagishi S, et al.
Source: Biochemical and Biophysical Research Communications, August 2002, 296(4):877-82

Advanced Glycation End Products Increase, Through a Protein Kinase C-Dependent Pathway, Vascular Endothelial Growth Factor Expression in Retinal Endothelial Cells. Inhibitory Effect of Gliclazide
Author: Mamputu JC and Renier G.
Source: Diabetes Complications, Jul-Aug 2002,16(4):284-93

Advanced Glycation End Products in Descemet's Membrane and Their Effect on Corneal Endothelial Cell
Author: Kaji Y, et al.
Source: Current Eye Research, December 2001, 23(6):469-77

Advanced Glycation: An Important Pathological Event in diabetic and age related ocular disease
Author: Stitt
Source: British Journal of Ophthalmology, 2001, 85:746–753

Advanced glycation end products in human optic nerve head
Author: Amano, et al.
Source: British Journal of Ophthalmology, 2001,85:52–55