Musculoskeletal

The glycation of extracellular matrix proteins such as collagen and elastin depresses tissue flexibility and compliance and renders the matrix less susceptible to degradation by metalloproteinases. The accumulation of A.G.E.s in the synovial linings of joints is associated with an inflammatory process and ultimately leads to cartilage degradation in arthritis.

Accumulation of Advanced Glycation End Products as a Molecular Mechanism for Aging as a Risk Factor in Osteoarthritis
Author: DeGroot, et al.
Source: Arthritis and Rheumatism, Vol 50, Issue 4 , 1207 – 1215 published online: April 2004

Expression of the Pro-Inflammatory Protein S100A12 (EN-RAGE) in Rheumatoid and Psoriatic Arthritis
Author: Foell, et al.
Source: Rheumatology (Oxford), 2003, 42(11):1383-9

AGEing and Osteoarthritis: A Different Perspective
Author: Verzijl, et al.
Source: Current Opinion in Rheumatology, 2003, 15(5):616-22

A Role for Advanced Glycation End Products in Diminished Bone Healing in Type 1 Diabetes
Author: Santana, et al.
Source: Diabetes, Vol. 52, June 2003

Advanced Glycation Endproducts and Osteoarthritis
Author: Saudek and Kay
Source: Current Rheumatology Reports, 2003, 5(1):33-40

Advanced Glycation End-Product (AGE)-Damaged IgG and IgM Autoantibodies to IgG-AGE in Patients With Early Synovitis
Author: Newkirk, et al.
Source: Arthritis Research and Therapy, Vol. 5, No. 2, 2003

Identification of the Advanced Glycation End Products N(epsilon)-Carboxymethyllysine in the Synovial Tissue of Patients with Rheumatoid Arthritis
Author: Drinda, et al.
Source: Annals of the Rheumatic Diseases, 2002 61(6):488-92

Crosslinking by Advanced Glycation End Products Increases the Stiffness of the Collagen Network in Human Articular Cartilage: A Possible Mechanism Through Which Age is a Risk Factor for Osteoarthritis
Author: Verzijl N, et al.
Source: Arthritis and Rheumatism, 2002, 46(1):114-23

Accumulation of Advanced Glycation Endproducts Reduces Chondrocyte-Mediated Extracellular Matrix Turnover in Human Articular Cartilage
Author: DeGroot, et al.
Source: Osteoarthritis Cartilage, 2001, 9(8):720-6

Age-Related Decrease in Susceptibility of Human Articular Cartilage to Matrix Metalloproteinase-Mediated Degradation: The Role of Advanced Glycation End Products
Author: DeGroot, et al.
Source: Arthritis and Rheumatism, 2001, 44(11):2562-71