Central Nervous System

A.G.E.s accumulate in the central nervous system in neurofibrillary tangles and plaque which are associated with Alzheimer’s disease. Additionally, it is thought that the reactive oxygen species associated with the presence of A.G.E.s is in part responsible for neuronal death in Alzheimer’s disease. Synvista is supporting preclinical research in this area of interest.

Oxidative Stress and Neurodegeneration
Author: Moreira, et al
Source: Ann. N.Y. Acad. Sci. 1043: 545–552, 2005

Age- and Stage-dependent Accumulation of Advanced Glycation End Products in Intracellular Deposits in Normal and Alzheimer’s Disease Brains
Author: Luth, et al
Source: Advance Access publication, July 6, 2004

Does Diabetes Protect or Provoke Alzheimer’s Disease? Insights Into the Pathobiology and Future Treatment of Alzheimer’s Disease
Author: Grossman
Source: CNS Spectrums, Vol. 8, No. 11, November 2003

Advanced Glycation End Products in Alzheimer’s Disease and Other Neurodegenerative Diseases
Author: Sasaki, et al.
Source: American Journal of Pathology, Vol. 153, No. 4, October 1998

Neurotoxicity of Advanced Glycation Endproducts During Focal Stroke and Neuroprotective Effects of Aminoguanidine
Author: Zimmerman, et al.
Source: Proceedings of the National Academy of Sciences, USA, Vol. 92, pp. 3744-3748, April 1995